"Finasteride + depression study" Wed Sep-15-04 08:26 PM by HairSite
Finasteride is linked to mood disturbance, mild to severe depression.
Journal of Drugs in Dermatology
January 01, 2003
finasteride, mood disturbance, treatment, minimal adverse, adrogenetic alopecia, adverse effects, aga, study developed, mg/day orally, severe depression, patients, depression, significatively impaired, impaired sociofamilial, researchers evaluated FINASTERIDE IS USED IN THE TREATMENT OF ADROGENETIC alopecia (AGA) and has been shown to have minimal adverse effects. In this study, researchers evaluated the effect of finasteride on mood disturbance.
23 patients were treated with finasteride, 1 mg/day orally, for AGA. 19/23 patients in this study developed a mood disturbance (moderate to severe depression) during treatment. Depression, which significatively impaired sociofamilial relations, sleep, and eating behavior, was associated to marked anxiety in some cases, developed after 9-19 weeks of treatment with finasteride, and promptly resolved after suspension of the drug. Two patients accepted reintroduction to the drag, and depression relapsed ...
Depression circumstantially related to the administration of finasteride for androgenetic alopecia.
Altomare G, Capella GL.
Department of Dermatology, Ospedale Maggiore IRCCS, University of Milan, Italy.
In this paper we report 19 patients (14 males, 5 females; mean age 28.16 years +/- 7.68 SD) out of a series of 23 (17 males, 5 females) who developed a mood disturbance (moderate to severe depression) during treatment with finasteride, 1 mg/day orally, for androgenetic alopecia (Hamilton subtypes III-V; Ludwig subtypes I-II). Depression, which significatively impaired sociofamilial relations, sleep and eating behaviour, was associated to marked anxiety in some cases, developed after 9-19 weeks of treatment with finasteride, and promptly resolved after suspension of the drug. Two patients accepted reintroduction of the drug, and depression relapsed within 2 weeks. Depression as an adverse effect of finasteride has been reported only once. Further studies are needed to confirm our circumstantial observations, which are based on a retrospective series of patients.
Finasteride: suspected association with depression
A white man in his mid-40s with no prior history of psychiatric problems was treated with finasteride for male-pattern hair loss. Clinical depression developed about 3 months after the onset of therapy. The depression was described as moderately severe but was unresponsive to treatment with various antidepressants. Treatment was maintained for 4 years. Following cessation of the finasteride therapy, the depression resolved in about 2 weeks, and the patient made a complete recovery. A published report has described 19 cases (14 males, 5 females) in whom moderate to severe depression developed during treatment with finasteride (1 mg/d orally) for androgenetic alopecia.1
1. Altomare G, Capella GL. Depression circumstantially related to the administration of finasteride for androgenetic alopecia. J Dermatol 2002;29(10):665-9.
#1. "RE: Finasteride + depression study" In response to Reply # 0 Thu Sep-16-04 10:56 AM by LiveHair
Isn't this quite disturbing?
It seems like it is almost a given that you would get some sort of depression ? moderate to severe depression - when on the drug. Right?
On the other hand I guess a lot of people would be depressed when loosing their hair too ? maybe not the guys in the study though ? - so whatever you do you will get depressed! What a golden option!
PS Hairsite does this info come from the same or different studies? You say "Another study", but the same number of patients are used in both studies, 23, and both studies shows effect on mood in 19 patients. Just wondering.
#2. "RE: Finasteride + depression study" In response to Reply # 1 Thu Sep-16-04 11:51 AM by GeminiX
I've generally experienced some depression whilst being on the drug. Luckily I'm usually able to shrug it off as I'm aware that it's just chemically induced, also a lot of good things have been happeneing in my life recently so that's probably helping too.